The Science

Decades of scientific investigation guides our work to solve this public health crisis.

Research shows that the adversity we experience as children can affect us into adulthood. Challenges children face in school, life – and ultimately with their health – are often the symptoms of ACEs and toxic stress.

The good news is, the earlier we can identify that a child is experiencing ACEs and toxic stress, the sooner children and families can be connected to the services they need to prevent or heal the effects.

The Landmark Adverse Childhood Experiences Study

The term “Adverse Childhood Experiences,” or “ACEs,” comes from the 1998 Adverse Childhood Experiences Study (ACE Study). The study,  a partnership between Kaiser Permanente and the U.S. Centers for Disease Control and Prevention (CDC), is one of the largest investigations ever conducted to assess connections between chronic stress caused by early adversity and long-term health.

The study examined exposure to childhood adversity, including abuse and neglect, and household dysfunction like domestic violence, parental mental illness, or parental substance abuse. Researchers assigned an “ACE score” to each participant by adding up the number of adversities the participant reported.

This ACE research had two striking findings:


ACEs are incredibly common.


The more ACEs, the higher risk for chronic disease as an adult


had four or more ACEs


had at least one ACE


Risk for heart disease or lung cancer with high ACE score.


Difference in life expectancy for children left untreated for high ACE score

Toxic Stress Research

Exposure to intense, frequent, or sustained stress without the buffering care of a supportive adult, can change children’s brains and bodies, including disrupting learning, behavior, immunity, growth, hormonal systems, immune systems, and even the way DNA is read and transcribed.


Disruption to the developing brain, including changes to the hippocampus, prefrontal cortex and amygdala, may lead to an increase in risk of cognitive impairment, attention deficits, learning disabilities, hyperactivity, self-regulation, memory and attention, and anxiety.

Cardiovascular system

Chronic inflammation may result in high blood pressure, damaged arteries, early hardening and narrowing of the arteries, risk of heart disease, heart attack, and stroke.

Immune system

Higher risk of infection and autoimmune disease may occur due to chronic inflammation and other factors, which cause changes in the body’s natural immune defense responses.


High cortisol (the hormone the body releases when stressed) can affect production of growth hormone, thyroid-stimulating hormone and others, resulting in metabolic disorders.

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The Center for Youth Wellness (CYW) is not a crisis center and cannot provide professional resources or clinical consultation to individuals who are not our patients. Individuals experiencing urgent medical or psychiatric concerns should call 911 or their local emergency service agency for immediate assistance.

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Center for Youth Wellness is not a crisis center. Those experiencing urgent medical or psychiatric concerns should dial 911 or their local emergency agency for assistance. We are unable to respond to messages requesting referrals, treatment or clinical consultations from individuals who are not our patients.